Self-perceived memory impairment in the setting of white-matter changes may signal Alzheimer’s, but, perhaps surprisingly, not vascular dementia, new study results suggest. “We found that elderly subjects with white-matter changes complaining of memory problems had a higher risk of dementia,” lead author Ana Verdelho, MD, from the Santa Maria Hospital at the University of Lisbon, in Portugal, told Medscape Neurology.

“When we analyzed the subtypes of dementia, the risk of Alzheimer’s disease was remarkable — 17-fold higher in the elderly complaining of memory difficulties.”
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